CAPTIVATE study: outcomes in patients with uMRD following cessation of ibrutinib plus venetoclax from umrd Watch Video

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VJHemOnc – Video Journal of Hematology u0026 HemOnc

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Prof Feugier speaks with ecancer at EHA 23 about results from a phase II trial of treating CLL with induction obinutuzumab and ibrutinib.nnHe describes how CR with undetectable residual disease (uMRD) may be associated with a longer survival in CLL.nnWith a manageable toxicity profile, 48% CR rate and 12.5% uMRD at 9 months, Prof Feugier describes the need for further research and further rounds of immunochemotherapy to fully induce uMRD.
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Dr Arnon Kater speaks to ecancer about the Glow study. nnThis is the first prospective data on minimal residual disease (MRD) outcomes after fixed-duration ibrutinib plus venetoclax (Ibr+Ven) versus chlorambucil plus obinutuzumab (Clb+O) for first-line treatment of CLL in elderly or unfit patients. nnInitially, he explains the background of the Glow study. nnDr Kater then discusses the methods and key results. All-oral, once-daily, fixed-duration Ibr+Ven demonstrated superior uMRD responses that
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